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Article

Identification of a Constitutively Active Mutant Mouse IRAK2 by Retroviral Expression Screening.

Molecular biotechnology - 1 Apr 2018

Liu Yanmei, Yin Weilan, Xu Lingqing, Zhang Helin, Liu Qian, Yin Weiguo

Abstract excerpt

To identify the importance of IRAK2 kinase activity in TLR-mediated signaling pathways, we constructed a retroviral vector harboring either a mouse IRAK2 gene (IRAK2-WT) or with its mutant with loss of function of its ATP-binding site (IRAK2-KD). Further, we comparatively analyzed for the gain of function and modulations in TLR-mediated signaling pathways in IRAK2 knockout (IRAK2-KO) macrophages upon introduction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1 Receptor-Associated Kinases

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Source

Identifiers

PMID: 29468521
DOI: 10.1007/s12033-018-0064-9

Genes

IRAK2
IRAK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Identification of a Constitutively Active Mutant Mouse IRAK2 by Retroviral Expression Screening.PMID 29468521Read ↗

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