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Article

IRAK-4 kinase activity-dependent and -independent regulation of lipopolysaccharide-inducible genes.

European journal of immunology - 1 Mar 2008

Koziczak-Holbro Magdalena, Glück Anton, Tschopp Claude, Mathison John C, Gram Hermann

Abstract excerpt

IRAK-4 kinase inactive (IRAK-4 KD) knock-in mice display defects in TLR- and IL-1 receptor signaling and are resistant to LPS-induced shock. In the present study we examined the LPS-induced response in IRAK-4 KD mice in more detail. We show that IRAK-4 kinase activity is required for certain aspects of TLR-mediated signaling but not for others. We found that IRAK-4 KD cells displayed reduced JNK and p38...

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Source

Identifiers

PMID: 18266302
DOI: 10.1002/eji.200737886

Genes

TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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IRAK-4 kinase activity-dependent and -independent regulation of lipopolysaccharide-inducible genes.PMID 18266302Read ↗

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