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Article

Assessment of bone marrow lymphocytic status during tyrosine kinase inhibitor therapy and its relation to therapy response in chronic myeloid leukaemia.

Journal of cancer research and clinical oncology - 1 May 2016

El Missiry Mohamed, Adnan Awad Shady, Rajala Hanna L, Al-Samadi Ahmed, Ekblom Marja, Markevän Berit, Åstrand-Grundström Ingbritt, Wold Maren, Svedahl Ellen Rabben, Juhl Birgitte Ravn, Bjerrum Ole Weis, Haulin Inger, Porkka Kimmo, Olsson-Strömberg Ulla, Hjorth-Hansen Henrik, Mustjoki Satu

Abstract excerpt

PURPOSE: Tyrosine kinase inhibitors (TKIs) used in the treatment of chronic myeloid leukaemia have been reported to induce immunomodulatory effects. We aimed to assess peripheral blood (PB) and bone marrow (BM) lymphocyte status at the diagnosis and during different TKI therapies and correlate it with treatment responses. METHODS: BM and PB samples were acquired from 105 first-line TKI-treated patients. Relative...

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Share to Bone Marrow
Share to Cytogenetic Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytotoxicity, Immunologic

Share to Dasatinib

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Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Source

Identifiers

PMID: 26746653
DOI: 10.1007/s00432-015-2101-4

Genes

ABL1
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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