Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Imatinib and Nilotinib Off-Target Effects on Human NK Cells, Monocytes, and M2 Macrophages

13 Jul 2017

Abstract excerpt

Tyrosine kinase inhibitors (TKIs) are used in the clinical management of hematological neoplasms. Moreover, in solid tumors such as stage 4 neuroblastomas (NB), imatinib showed benefits that might depend on both on-target and immunological off-target effects. We investigated the effects of imatinib and nilotinib on human NK cells, monocytes, and macrophages. High numbers of monocytes died upon exposure to TKI...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Chronic Myeloid Leukemia Treatments
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28701512
DOI: 10.4049/jimmunol.1601695

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Imatinib and Nilotinib Off-Target Effects on Human NK Cells, Monocytes, and M2 MacrophagesPMID 28701512Read ↗

The BCR-ABL inhibitor nilotinib influences phenotype and function of monocyte-derived human dendritic cells.Semantic proximity Read ↗

A MALDI-TOF assay identifies nilotinib as an inhibitor of inflammation in acute myeloid leukaemiaSemantic proximity Read ↗

Natural killer cell receptors and ligand variants modulate response to tyrosine kinase inhibitors in patients with chronic myeloid leukemia.Semantic proximity Read ↗

CD56 regulates human NK cell cytotoxicity through Pyk2Semantic proximity Read ↗

IFN‐α treatment may enable discontinuation of TKIs in NK cell‐licensed patients with CML‐CPSemantic proximity Read ↗

Implication of Interleukin-12/15/18 and Ruxolitinib in the Phenotype, Proliferation, and Polyfunctionality of Human Cytokine-Preactivated Natural Killer Cells.Semantic proximity Read ↗

Decitabine has a biphasic effect on natural killer cell viability, phenotype, and function under proliferative conditions.Semantic proximity Read ↗

Genotypes of NK cell KIR receptors, their ligands, and Fcγ receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy.Semantic proximity Read ↗

Neuroblastoma-Derived TGF-β1 Modulates the Chemokine Receptor Repertoire of Human Resting NK CellsSemantic proximity Read ↗

Imatinib mesylate minimally affects bcr-abl+ and normal monocyte-derived dendritic cells but strongly inhibits T cell expansion despite reciprocal dendritic cell-T cell activation.Semantic proximity Read ↗

Effect of LRRK2 protein and activity on stimulated cytokines in human monocytes and macrophagesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.