Article
Genetic or pharmacological superoxide-hydrogen peroxide imbalances modulate the in vitro effects of lithium on glycogen synthase kinase-3β.
Gene - 20 May 2018
Barbisan Fernanda, Azzolin Verônica Farina, Monteiro Gustavo Cardenas, Teixeira Cibele F, Mastella Moisés Henrique, Bueno Vitor, Duarte Marta Maria Medeiros Frescura, Wagner Glauber, do Prado-Lima Pedro Antônio Schmidt, Ribeiro Euler Esteves, da Cruz Ivana B M
Abstract excerpt
INTRODUCTION: Lithium (Li), a mood stabilizer used to treat bipolar disorder (BP) symptoms has important anti-inflammatory effects by downregulation of glycogen synthase kinase-3 beta (GSK-3β). However, sometime Li effect is not efficient in some patients suggesting genetic interference. Previous investigations described association between a genetic superoxide‑hydrogen (S-HP) imbalance caused by a superoxide...
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