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Article

Combination Approach for Detecting Different Types of Alterations in Circulating Tumor DNA in Leiomyosarcoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2018

Przybyl Joanna, Chabon Jacob J, Spans Lien, Ganjoo Kristen N, Vennam Sujay, Newman Aaron M, Forgó Erna, Varma Sushama, Zhu Shirley, Debiec-Rychter Maria, Alizadeh Ash A, Diehn Maximilian, van de Rijn Matt

Abstract excerpt

Purpose: The clinical utility of circulating tumor DNA (ctDNA) monitoring has been shown in tumors that harbor highly recurrent mutations. Leiomyosarcoma represents a type of tumor with a wide spectrum of heterogeneous genomic abnormalities; thus, targeting hotspot mutations or a narrow genomic region for ctDNA detection may not be practical. Here, we demonstrate a combinatorial approach that integrates different...

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Share to DNA Copy Number Variations
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29463554
DOI: 10.1158/1078-0432.CCR-17-3704
PMCID: PMC5984700

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