Article
Circulating Tumor DNA Is Associated with Response and Survival in Patients with Advanced Leiomyosarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 13 Jun 2022
Madanat-Harjuoja Laura M, Klega Kelly, Lu Yao, Shulman David S, Thorner Aaron R, Nag Anwesha, Tap William D, Reinke Denise K, Diller Lisa, Ballman Karla V, George Suzanne, Crompton Brian D
Abstract excerpt
PURPOSE: We sought to determine whether the detection of circulating tumor DNA (ctDNA) in samples of patients undergoing chemotherapy for advanced leiomyosarcoma (LMS) is associated with objective response or survival. EXPERIMENTAL DESIGN: Using ultra-low-passage whole-genome sequencing (ULP-WGS) of plasma cell-free DNA from patients treated on a prospective clinical trial, we tested whether detection of ctDNA...
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