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Article

A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics.

PloS one - 1 Jan 2018

Mav Deepak, Shah Ruchir R, Howard Brian E, Auerbach Scott S, Bushel Pierre R, Collins Jennifer B, Gerhold David L, Judson Richard S, Karmaus Agnes L, Maull Elizabeth A, Mendrick Donna L, Merrick B Alex, Sipes Nisha S, Svoboda Daniel, Paules Richard S

Abstract excerpt

Changes in gene expression can help reveal the mechanisms of disease processes and the mode of action for toxicities and adverse effects on cellular responses induced by exposures to chemicals, drugs and environment agents. The U.S. Tox21 Federal collaboration, which currently quantifies the biological effects of nearly 10,000 chemicals via quantitative high-throughput screening(qHTS) in in vitro model systems,...

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PMID: 29462216
DOI: 10.1371/journal.pone.0191105
PMCID: PMC5819766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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