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OAS1, 2, and 3: Significance During Active Tuberculosis?

12 Feb 2018

Abstract excerpt

Evidence to-date points to a detrimental role of the type I IFNs during tuberculosis. The mechanisms underpinning the IFNαβ-mediated exacerbation of the disease is unclear. The 2'-5'-oligoadenylate synthetases (OAS), namely OAS1, OAS2 and OAS3 are part of the interferon-induced genes which until now have been synonymous with an anti-viral function. Blood transcriptome profiling has continuously observed their...

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PMID: 29452387
DOI: 10.1093/infdis/jiy084

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