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Article

Simulated ablation for detection of cells impacting paracrine signalling in histology analysis.

Mathematical medicine and biology : a journal of the IMA - 14 Mar 2019

Taylor-King Jake P, Baratchart Etienne, Dhawan Andrew, Coker Elizabeth A, Rye Inga Hansine, Russnes Hege, Chapman S Jon, Basanta David, Marusyk Andriy

Abstract excerpt

Intra-tumour phenotypic heterogeneity limits accuracy of clinical diagnostics and hampers the efficiency of anti-cancer therapies. Dealing with this cellular heterogeneity requires adequate understanding of its sources, which is extremely difficult, as phenotypes of tumour cells integrate hardwired (epi)mutational differences with the dynamic responses to microenvironmental cues. The later comes in form of both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29452382
DOI: 10.1093/imammb/dqx022
PMCID: PMC7197102

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