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Article

Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.

Nature communications - 9 Dec 2014

Shen Keyue, Luk Samantha, Hicks Daniel F, Elman Jessica S, Bohr Stefan, Iwamoto Yoshiko, Murray Ryan, Pena Kristen, Wang Fangjing, Seker Erkin, Weissleder Ralph, Yarmush Martin L, Toner Mehmet, Sgroi Dennis, Parekkadan Biju

Abstract excerpt

Tumour-stromal interactions are a determining factor in cancer progression. In vivo, the interaction interface is associated with spatially resolved distributions of cancer and stromal phenotypes. Here, we establish a micropatterned tumour-stromal assay (μTSA) with laser capture microdissection to control the location of co-cultured cells and analyse bulk and interfacial tumour-stromal signalling in driving...

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Identifiers

PMID: 25489927
DOI: 10.1038/ncomms6662
PMCID: PMC4261930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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