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Article

Association between Oxidative Stress, Genetic Factors, and Clinical Severity in Children with Sickle Cell Anemia.

The Journal of pediatrics - 1 Apr 2018

Renoux Céline, Joly Philippe, Faes Camille, Mury Pauline, Eglenen Buse, Turkay Mine, Yavas Gokce, Yalcin Ozlem, Bertrand Yves, Garnier Nathalie, Cuzzubbo Daniela, Gauthier Alexandra, Romana Marc, Möckesch Berenike, Cannas Giovanna, Antoine-Jonville Sophie, Pialoux Vincent, Connes Philippe

Abstract excerpt

OBJECTIVES: To investigate the associations between several sickle cell disease genetic modifiers (beta-globin haplotypes, alpha-thalassemia, and glucose-6-phosphate dehydrogenase deficiency) and the level of oxidative stress and to evaluate the association between oxidative stress and the rates of vaso-occlusive events. STUDY DESIGN: Steady-state oxidative and nitrosative stress markers, biological variables,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29449005
DOI: 10.1016/j.jpeds.2017.12.021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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