Article
Significant prevalence of NR3C1 mutations in incidentally discovered bilateral adrenal hyperplasia: results of the French MUTA-GR Study.
European journal of endocrinology - 1 Apr 2018
Vitellius Géraldine, Trabado Séverine, Hoeffel Christine, Bouligand Jérôme, Bennet Antoine, Castinetti Frederic, Decoudier Bénédicte, Guiochon-Mantel Anne, Lombes Marc, Delemer Brigitte
Abstract excerpt
BACKGROUND: Recently discovered mutations of NR3C1 gene, encoding for the GR, in patients with glucocorticoid resistance and bilateral adrenal incidentalomas prompted us to investigate whether GR mutations might be associated with adrenal hyperplasia. OBJECTIVE: The multicenter French Clinical Research Program (Muta-GR) was set up to determine the prevalence of GR mutations and polymorphisms in patients harboring...
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