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Article

Identification of FAM173B as a protein methyltransferase promoting chronic pain.

PLoS biology - 1 Feb 2018

Willemen Hanneke L D M, Kavelaars Annemieke, Prado Judith, Maas Mirjam, Versteeg Sabine, Nellissen Lara J J, Tromp Jeshua, Gonzalez Cano Rafael, Zhou Wenjun, Jakobsson Magnus E, Małecki Jędrzej, Posthuma George, Habib Abdella M, Heijnen Cobi J, Falnes Pål Ø, Eijkelkamp Niels

Abstract excerpt

Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic widespread pain. This region includes the coding region for FAM173B, a functionally uncharacterized protein. We demonstrate here that FAM173B is a mitochondrial lysine methyltransferase that promotes...

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Identifiers

PMID: 29444090
DOI: 10.1371/journal.pbio.2003452
PMCID: PMC5828452

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Source receipt: pubmed, retrieved 7 Sept 2026.

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