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Article

Genome-wide methylation analysis of a large population sample shows neurological pathways involvement in chronic widespread musculoskeletal pain.

Pain - 1 Jun 2017

Livshits Gregory, Malkin Ida, Freidin Maxim B, Xia Yudong, Gao Fei, Wang Jun, Spector Timothy D, MacGregor Alex, Bell Jordana T, Williams Frances M K

Abstract excerpt

Chronic widespread musculoskeletal pain (CWP), has a considerable heritable component, which remains to be explained. Epigenetic factors may contribute to and account for some of the heritability estimate. We analysed epigenome-wide methylation using MeDIPseq in whole blood DNA from 1708 monozygotic and dizygotic Caucasian twins having CWP prevalence of 19.9%. Longitudinally stable methylation bins (lsBINs), were...

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Identifiers

PMID: 28221285
DOI: 10.1097/j.pain.0000000000000880
PMCID: PMC5427989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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