Article
Exploring the relationship between α-actinin-3 deficiency and obesity in mice and humans.
International journal of obesity (2005) - 1 Jul 2017
Houweling P J, Berman Y D, Turner N, Quinlan K G R, Seto J T, Yang N, Lek M, Macarthur D G, Cooney G, North K N
Abstract excerpt
Obesity is a worldwide health crisis, and the identification of genetic modifiers of weight gain is crucial in understanding this complex disorder. A common null polymorphism in the fast fiber-specific gene ACTN3 (R577X) is known to influence skeletal muscle function and metabolism. α-Actinin-3 deficiency occurs in an estimated 1.5 billion people worldwide, and results in reduced muscle strength and a shift...
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