Article
Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging.
Nature communications - 13 Feb 2018
Oh Gabriel, Ebrahimi Sasha, Carlucci Matthew, Zhang Aiping, Nair Akhil, Groot Daniel E, Labrie Viviane, Jia Peixin, Oh Edward S, Jeremian Richie H, Susic Miki, Shrestha Tenjin C, Ralph Martin R, Gordevičius Juozas, Koncevičius Karolis, Petronis Art
Abstract excerpt
Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian cytosine modifications at the nucleotide level have remained elusive. In this study, we report that a large...
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