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Inhibition of Human Papillomavirus Type 16 Infection Using an RNA Aptamer.

Nucleic acid therapeutics - 1 Apr 2018

Valencia-Reséndiz Diana Gabriela, Palomino-Vizcaino Giovanni, Tapia-Vieyra Juana Virginia, Benítez-Hess María Luisa, Leija-Montoya Ana Gabriela, Alvarez-Salas Luis Marat

Abstract excerpt

Human papillomavirus type 16 (HPV16) DNA has been found in ∼50% of cervical tumors worldwide. HPV infection starts with the binding of the virus capsid to heparan sulfate (HS) receptors exposed on the surface of epithelial basal layer keratinocytes. Previously, our group isolated a high-affinity RNA aptamer (Sc5c3) specific for HPV16 L1 virus-like particles (VLPs). In this study, we report the inhibition of HPV16...

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Identifiers

PMID: 29437522
DOI: 10.1089/nat.2017.0687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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