Article
Gene transfer using human papillomavirus pseudovirions varies according to virus genotype and requires cell surface heparan sulfate.
FEMS microbiology letters - 16 Oct 2001
Combita A L, Touzé A, Bousarghin L, Sizaret P Y, Muñoz N, Coursaget P
Abstract excerpt
Artificial viruses consisting of DNA plasmid packaged in vitro into virus-like particles (VLPs) are new vehicles for gene transfer. We therefore investigated the ability of nine human papillomavirus (HPV) VLPs to interact with heterologous DNA and transfer genes. HPV 16, 18, 31, 33, 39, 45, 58, 59, and 68 VLPs were able to bind heterologous DNA and to transfer genes into Cos-7 cells. Inhibition of gene transfer...
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