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Article

Targeting HPV16 DNA Using CRISPR/Cas Inhibits Anal Cancer Growth <i>in Vivo</i>

12 Jun 2018

Abstract excerpt

Aim: The goal of this study was to determine if a single AAV vector, encoding Cas9 and guide RNAs specific for the HPV16 E6 and E7 genes, could inhibit the growth of an HPV16-induced tumor in vivo. Materials & methods: We grew HPV16+, patient-derived anal cancer explants in immunodeficient mice and then challenged these by injection of AAV-based vectors encoding Cas9 and control or HPV16-specific guide RNAs....

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PMID: 30245733
DOI: 10.2217/fvl-2018-0010

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