Modeling the Growth and Decline of Pathogen Effective Population Size Provides Insight into Epidemic Dynamics and Drivers of Antimicrobial Resistance

Abstract excerpt

Nonparametric population genetic modeling provides a simple and flexible approach for studying demographic history and epidemic dynamics using pathogen sequence data. Existing Bayesian approaches are premised on stochastic processes with stationary increments which may provide an unrealistic prior for epidemic histories which feature extended period of exponential growth or decline. We show that nonparametric...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Evolution and Genetic Dynamics
• Share to Yersinia bacterium, plague, ectoparasites research
• Share to Zoonotic diseases and public health