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Article

Functionally significant polymorphisms of the MMP9 gene are associated with primary open-angle glaucoma in the population of Russia.

European journal of ophthalmology - 1 Nov 2022

Ponomarenko Irina, Reshetnikov Evgeny, Dvornyk Volodymyr, Churnosov Mikhail

Abstract excerpt

PURPOSE: The aim of this study was to investigate the role of functionally significant loci of the matrix metalloproteinases genes 1, 3, 9 (MMP1, MMP3, and MMP9) in the development of primary open-angle glaucoma (POAG) in Caucasians of the Central region of Russia. METHODS: In total 604 participants were recruited for the study, including 208 patients with POAG and 396 healthy controls. They were genotyped at...

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PMID: 35254145
DOI: 10.1177/11206721221083722

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