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Article

Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor.

Journal of the American Heart Association - 3 Feb 2018

Higaki Akinori, Mogi Masaki, Iwanami Jun, Min Li-Juan, Bai Hui-Yu, Shan Bao-Shuai, Kukida Masayoshi, Yamauchi Toshifumi, Tsukuda Kana, Kan-No Harumi, Ikeda Shuntaro, Higaki Jitsuo, Horiuchi Masatsugu

Abstract excerpt

BACKGROUND: The classical renin-angiotensin system is known as the angiotensin (Ang)-converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline. The angiotensin-converting enzyme 2/Ang-(1-7)/Mas axis is known to exert antagonistic actions against the classical renin-angiotensin system axis in the cardiovascular system. However, its roles in the brain remain...

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Identifiers

PMID: 29431106
DOI: 10.1161/JAHA.117.008121
PMCID: PMC5850265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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