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Article

A53T α-synuclein mutation increases susceptibility to postoperative delayed neurocognitive recovery via hippocampal Ang-(1-7)/MasR axis.

Biochemical pharmacology - 1 Jun 2024

Hong Jingshu, Li Yue, Chen Lei, Han Dengyang, Li Yitong, Mi Xinning, Liu Kaixi, Wang Qian, Song Yanan, Liu Taotao, Yang Ning, Liu Yajie, Li Zhengqian, Guo Xiangyang

Abstract excerpt

Delayed neurocognitive recovery (dNCR) is a common complication in geriatric surgical patients. The impact of anesthesia and surgery on patients with neurodegenerative diseases, such as Parkinson's disease (PD) or prion disease, has not yet been reported. In this study, we aimed to determine the association between a pre-existing A53T genetic background, which involves a PD-related point mutation, and the...

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Identifiers

PMID: 38705534
DOI: 10.1016/j.bcp.2024.116261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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