The COMT-polymorphism is not associated with the incidence of acute kidney injury after cardiac surgery - a prospective cohort study.

doi:10.1186/s12882-018-0820-x

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Article

The COMT-polymorphism is not associated with the incidence of acute kidney injury after cardiac surgery - a prospective cohort study.

BMC nephrology - 9 Feb 2018

Oezkur Mehmet, Magyar Attila, Thomas Phillip, Reif Andreas, Störk Stefan, Heuschmann Peter U, Leyh Rainer G, Wagner Martin

Abstract excerpt

BACKGROUND: The Catechol-O-methyltransferase (COMT) represents the key enzyme in catecholamine degradation. Recent studies suggest that the COMT rs4680 polymorphism is associated with the response to endogenous and exogenous catecholamines. There are, however, conflicting data regarding the COMT Met/Met phenotype being associated with an increased risk of acute kidney injury (AKI) after cardiac surgery. The aim...

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PMID: 29426301
DOI: 10.1186/s12882-018-0820-x
PMCID: PMC5807752

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COMT

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