Article
Physiologic Interpretation of GWAS Signals for Type 2 Diabetes.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018
Watanabe Richard M
Abstract excerpt
This chapter reviews both statistical and physiologic issues related to the pathophysiologic effects of genetic variation in the context of type 2 diabetes. The goal is to review current methodologies used to analyze disease-related quantitative traits for those who do not have extensive quantitative and physiologic background, as an attempt to bridge that gap. We leverage mathematical modeling to illustrate the...
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