Article
Poly(rC) binding protein 2 acts as a negative regulator of IRES-mediated translation of Hr mRNA.
Experimental & molecular medicine - 9 Feb 2018
Kim Jeong-Ki, Kim Injung, Choi Keonwoo, Choi Jee-Hyun, Kim Eunmin, Lee Hwa-Young, Park Jongkeun, Kim Yoon Sungjoo
Abstract excerpt
During the hair follicle (HF) cycle, HR protein expression is not concordant with the presence of the Hr mRNA transcript, suggesting an elaborate regulation of Hr gene expression. Here we present evidence that the 5' untranslated region (UTR) of the Hr gene has internal ribosome entry site (IRES) activity and this activity is regulated by the binding of poly (rC) binding protein 2 (PCBP2) to Hr mRNA....
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