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Article

RMRP is a non-coding RNA essential for early murine development.

PloS one - 1 Jan 2011

Rosenbluh Joseph, Nijhawan Deepak, Chen Zhao, Wong Kwok-Kin, Masutomi Kenkichi, Hahn William C

Abstract excerpt

RMRP is a non-coding RNA that is ubiquitously expressed in both humans and mice. RMRP mutations that lead to decreased RMRP levels are found in the pleiotropic syndrome Cartilage Hair Hypoplasia. To assess the effects of deleting RMRP, we engineered a targeting vector that contains loxP sequences flanking RMRP and created hemizygous mice harboring this engineered allele (RMRP conditional). We found that insertion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22039455
DOI: 10.1371/journal.pone.0026270
PMCID: PMC3198473

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RMRP is a non-coding RNA essential for early murine development.PMID 22039455Read ↗

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RMRP variants inhibit the cell cycle checkpoints pathway in cartilage‑hair hypoplasiaSemantic proximity Read ↗

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