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Article

RNA expression profiling in lymphoblastoid cell lines from mutated and non-mutated amyotrophic lateral sclerosis patients.

The journal of gene medicine - 1 Jul 2024

Garau Jessica, Garofalo Maria, Dragoni Francesca, Scarian Eveljn, Di Gerlando Rosalinda, Diamanti Luca, Zucca Susanna, Bordoni Matteo, Pansarasa Orietta, Gagliardi Stella

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the death of upper and lower motor neurons with an unknown etiology. The difficulty of recovering biological material from patients led to employ lymphoblastoid cell lines (LCLs) as a model for ALS because many pathways, typically located in neurons, are also activated in these cells. METHODS: To investigate the...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38967638
DOI: 10.1002/jgm.3711

Genes

C9ORF72
FUS
SOD1
TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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