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Article

Monogenic Causes in the Type 1 Diabetes Genetics Consortium Cohort: Low Genetic Risk for Autoimmunity in Case Selection.

The Journal of clinical endocrinology and metabolism - 13 May 2021

Marchand Luc, Li Meihang, Leblicq Coralie, Rafique Ibrar, Alarcon-Martinez Tugba, Lange Claire, Rendon Laura, Tam Emily, Courville-Le Bouyonnec Ariane, Polychronakos Constantin

Abstract excerpt

HYPOTHESIS: About 1% of patients clinically diagnosed as type 1 diabetes have non-autoimmune monogenic diabetes. The distinction has important therapeutic implications but, given the low prevalence and high cost of testing, selecting patients to test is important. We tested the hypothesis that low genetic risk for type 1 diabetes can substantially contribute to this selection. METHODS: As proof of principle, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33538814
DOI: 10.1210/clinem/dgab056
PMCID: PMC8118360

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