Article
Genetic Diversity and Selection of Plasmodium vivax Apical Membrane Antigen-1 in China-Myanmar Border of Yunnan Province, China, 2009-2016.
Frontiers in cellular and infection microbiology - 1 Jan 2021
Cui Yan-Bing, Shen Hai-Mo, Chen Shen-Bo, Kassegne Kokouvi, Shi Tian-Qi, Xu Bin, Chen Jun-Hu, Wu Jia-Hong, Wang Yue
Abstract excerpt
Plasmodium vivax apical membrane antigen-1 (PvAMA-1) is an important vaccine candidate for vivax malaria. However, antigenic variation within PvAMA-1 is a major obstacle to the design of a global protective malaria vaccine. In this study, we analyzed the genetic polymorphism and selection of the PvAMA-1 gene from 152 P. vivax isolates from imported cases to China, collected in the China-Myanmar border (CMB) area...
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