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Article

Evaluation of KRAS Concomitant Mutations in Advanced Lung Adenocarcinoma Patients.

Medicina (Kaunas, Lithuania) - 29 Sept 2021

Aran Veronica, Zalis Mariano, Montella Tatiane, de Sousa Carlos Augusto Moreira, Ferrari Bruno L, Gil Ferreira Carlos

Abstract excerpt

Background and Objectives: One of the most frequently mutated oncogenes in cancer belongs to the Ras family of proto-oncogenes, which encode distinct key signaling events. RAS gain-of-function mutations are present in ~30% of all human cancers, with KRAS being the most frequently mutated isoform showing alterations in different cancer types including lung cancer. This study aimed to investigate the incidence of...

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Identifiers

PMID: 34684076
DOI: 10.3390/medicina57101039
PMCID: PMC8539053

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