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Article

Can Mutational Analysis Be Used To Assist Structure Determination of Peptides?

Journal of the American Chemical Society - 21 Feb 2018

Voronina Liudmila, Scutelnic Valeriu, Masellis Chiara, Rizzo Thomas R

Abstract excerpt

Mutational analysis is widely used to study the relationship between sequence and structure of proteins and peptides. It is often assumed that substituting a proline with another amino acid "locks" the peptide bond in the trans conformation, allowing only a subset of the initial molecular geometries to be observed. To test this assumption, we assess the result of substituting two prolines in the bradykinin...

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PMID: 29412650
DOI: 10.1021/jacs.7b11302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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