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Article

P209L mutation in Bag3 does not cause cardiomyopathy in mice

30 Nov 2018

Abstract excerpt

Bcl-2-associated athanogene 3 (BAG3) is a cochaperone protein and a central player of the cellular protein quality control system. BAG3 is prominently expressed in the heart and plays an essential role in cardiac protein homeostasis by interacting with chaperone heat shock proteins (HSPs) in large, functionally distinct multichaperone complexes. The BAG3 mutation of proline 209 to leucine (P209L), which resides...

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Identifiers

PMID: 30499714
DOI: 10.1152/ajpheart.00714.2018

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