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Article

Attenuation of reactive gliosis in stroke-injured mouse brain does not affect neurogenesis from grafted human iPSC-derived neural progenitors.

PloS one - 1 Jan 2018

Laterza Cecilia, Uoshima Naomi, Tornero Daniel, Wilhelmsson Ulrika, Stokowska Anna, Ge Ruimin, Pekny Milos, Lindvall Olle, Kokaia Zaal

Abstract excerpt

Induced pluripotent stem cells (iPSCs) or their progeny, derived from human somatic cells, can give rise to functional improvements after intracerebral transplantation in animal models of stroke. Previous studies have indicated that reactive gliosis, which is associated with stroke, inhibits neurogenesis from both endogenous and grafted neural stem/progenitor cells (NSPCs) of rodent origin. Here we have assessed...

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Identifiers

PMID: 29401502
DOI: 10.1371/journal.pone.0192118
PMCID: PMC5798785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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