Article
General misincorporation frequency: Re-evaluation of the fidelity of DNA polymerases.
Biochemical and biophysical research communications - 19 Feb 2018
Yang Jie, Li Bianbian, Liu Xiaoying, Tang Hong, Zhuang Xiyao, Yang Mingqi, Xu Ying, Zhang Huidong, Yang Chun
Abstract excerpt
DNA replication in cells is performed in the presence of four dNTPs and four rNTPs. In this study, we re-evaluated the fidelity of DNA polymerases using the general misincorporation frequency consisting of three incorrect dNTPs and four rNTPs but not using the traditional special misincorporation frequency with only the three incorrect dNTPs. We analyzed both the general and special misincorporation frequencies...
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