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Role of polymorphic XRCC6 (Ku70)/XRCC7 (DNA-PKcs) genes towards susceptibility and prognosis of lung cancer patients undergoing platinum based doublet chemotherapy.

Molecular biology reports - 1 Jun 2018

Singh Amrita, Singh Navneet, Behera Digambar, Sharma Siddharth

Abstract excerpt

The DNA repair genes XRCC6 and XRCC7 formed an integral part of double strand break repair (DSBR) pathway. The two genes are thought to play an important role in the repair of lethal double strand damage on DNA. Polymorphic DSBR genes are studied to effect genomic stability. We intend to explore the association of DSBR genes i.e. XRCC6 and XRCC7 with susceptibility and survival in North Indian lung cancer...

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Identifiers

PMID: 29397516
DOI: 10.1007/s11033-018-4158-z

Genes

XRCC6

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