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Article

Pharmacokinetic and pharmacodynamic re-evaluation of a genetic-guided warfarin trial.

European journal of clinical pharmacology - 1 May 2018

Zambon Carlo Federico, Pengo Vittorio, Moz Stefania, Bozzato Dania, Fogar Paola, Padoan Andrea, Plebani Mario, Groppa Francesca, De Rosa Giovanni, Padrini Roberto

Abstract excerpt

PURPOSE: A previous trial failed to demonstrate the superiority of a demographic-genetic algorithm in predicting warfarin (W) dose over a standard clinical approach. The purpose of the present study is to re-analyse the results in subgroups of patients with differing baseline sensitivity to W, integrated with additional pharmacokinetic data. METHODS: The original trial allocated 180 treatment-naïve patients with...

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Source

Identifiers

PMID: 29396738
DOI: 10.1007/s00228-018-2422-8

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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