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Article

Genetic correction of adipose tissue-derived mesenchymal stem cells mediated by TALEN targeting the GDF5 gene.

International journal of molecular medicine - 1 Apr 2018

Li Baofeng, Zhang Ying, Li Mei, Zhao Xiaoliang, Xie Huibin, Guo Xiaoze, Wang Fei, Xia Hong, Chen Bei

Abstract excerpt

Stem cells and other associated cell types may be a potential alternative to treat various genetic disorders that currently do not benefit from traditional approaches. Functional recovery of cells could be induced via directional differentiation or genetic manipulation. In this study, mesenchymal stem cells (MSCs) were obtained from a patient with osteoarthritis (OA) carrying a functional single‑nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29393424
DOI: 10.3892/ijmm.2018.3442

Genes

GDF5
MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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