Article
Identification of recurrent SMO and BRAF mutations in ameloblastomas.
Nature genetics - 1 Jul 2014
Sweeney Robert T, McClary Andrew C, Myers Benjamin R, Biscocho Jewison, Neahring Lila, Kwei Kevin A, Qu Kunbin, Gong Xue, Ng Tony, Jones Carol D, Varma Sushama, Odegaard Justin I, Sugiyama Toshihiro, Koyota Souichi, Rubin Brian P, Troxell Megan L, Pelham Robert J, Zehnder James L, Beachy Philip A, Pollack Jonathan R, West Robert B
Abstract excerpt
Here we report the discovery of oncogenic mutations in the Hedgehog and mitogen-activated protein kinase (MAPK) pathways in over 80% of ameloblastomas, locally destructive odontogenic tumors of the jaw, by genomic analysis of archival material. Mutations in SMO (encoding Smoothened, SMO) are common in ameloblastomas of the maxilla, whereas BRAF mutations are predominant in tumors of the mandible. We show that a...
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