Article

Picornavirus Evolution: Genomes Encoding Multiple 2A<sup>NPGP</sup> Sequences – Biomedical and Biotechnological Utility

2024-09-25

Abstract excerpt

Alignment of picornavirus proteinase/polymerase sequences reveals this family evolved into five ‘supergroups’. Interestingly, the nature of the 2A region of the picornavirus polyprotein is highly correlated with this phylogeny. Viruses within supergroup 4, the Paavivirinae, have complex 2A regions with many viruses encoding multiple 2ANPGP sequences. In vitro transcription/translation analyses of a syn...

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Literature Corpus work: 4d79ebfb-a6f5-54d9-aa36-63384d73a52e
DOI: 10.20944/preprints202409.1973.v1

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