Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Combination of SAHA and Quinacrine Is Effective in Inducing Cancer Cell Death in Upper Gastrointestinal Cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2018

Zhu Shoumin, Chen Zheng, Wang Lihong, Peng Dunfa, Belkhiri Abbes, Lockhart A Craig, El-Rifai Wael

Abstract excerpt

Purpose: We aimed to investigate the therapeutic efficacy of single agent and the combination of quinacrine and suberoylanilide hydroxamic acid (SAHA) in wt- and mut-p53 upper gastrointestinal cancer (UGC) cell models.Experimental Design: ATP-Glo, clonogenic cell survival, Annexin V, comet, DNA double-strand breaks (DSBs), qPCR, and Western blot analysis assays were utilized.Results: Using clonogenic cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Synergism

Share to Drug Therapy, Combination

Share to Gastrointestinal Neoplasms

Share to Histone Deacetylase Inhibitors

Share to Vorinostat

Share to Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 29386219
DOI: 10.1158/1078-0432.CCR-17-1716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Combination of SAHA and Quinacrine Is Effective in Inducing Cancer Cell Death in Upper Gastrointestinal Cancers.PMID 29386219Read ↗

Chloroquine-induced DNA damage synergizes with DNA repair inhibitors causing cancer cell deathSemantic proximity Read ↗

Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer.Semantic proximity Read ↗

The in vitro and vivo anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) and MG132 on the aggressive phenotypes of gastric cancer cells.Semantic proximity Read ↗

Talazoparib enhances the Quinacrine-mediated apoptosis in patient-derived oral mucosa CSCs by inhibiting BER pathway through the modulation of GCN5 and P300Semantic proximity Read ↗

Long-lasting reduction in clonogenic potential of colorectal cancer cells by sequential treatments with 5-azanucleosides and topoisomerase inhibitors.Semantic proximity Read ↗

Depletion of runt-related transcription factor 2 (RUNX2) enhances SAHA sensitivity of p53-mutated pancreatic cancer cells through the regulation of mutant p53 and TAp63.Semantic proximity Read ↗

Talazoparib enhances the quinacrine-mediated apoptosis in patient-derived oral mucosa CSCs by inhibiting BER pathway through the modulation of GCN5 and P300Semantic proximity Read ↗

The PARP inhibitor ABT-888 potentiates dacarbazine-induced cell death in carcinoids.Semantic proximity Read ↗

Quinacrine-Mediated Autophagy and Apoptosis in Colon Cancer Cells Is Through a p53- and p21-Dependent MechanismSemantic proximity Read ↗

A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinomaSemantic proximity Read ↗

Inhibitor of Aurora Kinase B Induces Differentially Cell Death and Polyploidy via DNA Damage Response Pathways in Neurological Malignancy: Shedding New Light on the Challenge of Resistance to AZD1152-HQPA.Semantic proximity Read ↗

NCI 10211: a phase II, single-arm study of berzosertib in combination with irinotecan in patients with advanced TP53 mutant gastroesophageal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.