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Article

Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer.

Cancer biology & therapy - 1 Aug 2011

Gallant Jean-Nicolas, Allen Joshua E, Smith Charles D, Dicker David T, Wang Wenge, Dolloff Nathan G, Navaraj Arunasalam, El-Deiry Wafik S

Abstract excerpt

Although treatments have improved patient prognosis in surgically resectable colorectal cancer, new effective drugs with improved safety profiles are needed to improve the currently poor outcomes of patients with recurrent or metastatic colorectal cancer. Quinacrine, a small molecule anti-malarial agent that has activity in giardiasis, lupus, prion disease, and used as a means of non-surgical sterilization, has...

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Identifiers

PMID: 21725213
DOI: 10.4161/cbt.12.3.17034

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KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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