Article

Talazoparib enhances the Quinacrine-mediated apoptosis in patient-derived oral mucosa CSCs by inhibiting BER pathway through the modulation of GCN5 and P300

2023-10-09

Abstract excerpt

<title>Abstract</title> <p>The presence of cancer stem cells (CSCs) in the tumor microenvironment (TME) is majorly responsible for the development and recurrence of cancer. Earlier reports suggested that upon DNA damage, Poly-(ADP-ribose) Polymerase-1 (PARP-1) helps in chromatin modulation and DNA repair process, thereby promoting CSC survival. But whether a combination of DNA damaging agents along with PARP inhi...

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Literature Corpus work: fae2ee46-5520-549c-a8d8-b4f47a425570
DOI: 10.21203/rs.3.rs-3357641/v1

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Talazoparib enhances the Quinacrine-mediated apoptosis in patient-derived oral mucosa CSCs by inhibiting BER pathway through the modulation of GCN5 and P300DOI 10.21203/rs.3.rs-3357641/v1Read

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