Article
Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers.
PloS one - 1 Jan 2018
Kawaguchi Takahisa, Shima Toshihide, Mizuno Masayuki, Mitsumoto Yasuhide, Umemura Atsushi, Kanbara Yoshihiro, Tanaka Saiyu, Sumida Yoshio, Yasui Kohichiro, Takahashi Meiko, Matsuo Keitaro, Itoh Yoshito, Tokushige Katsutoshi, Hashimoto Etsuko, Kiyosawa Kendo, Kawaguchi Masanori, Itoh Hiroyuki, Uto Hirofumi, Komorizono Yasuji, Shirabe Ken, Takami Shiro, Takamura Toshinari, Kawanaka Miwa, Yamada Ryo, Matsuda Fumihiko, Okanoue Takeshi
Abstract excerpt
The genetic factors affecting the natural history of nonalcoholic fatty liver disease (NAFLD), including the development of nonalcoholic steatohepatitis (NASH) and NASH-derived hepatocellular carcinoma (NASH-HCC), are still unknown. In the current study, we sought to identify genetic factors related to the development of NAFLD, NASH, and NASH-HCC, and to establish risk-estimation models for them. For these...
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