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Article

Biochemical features of genetic Creutzfeldt-Jakob disease with valine-to-isoleucine substitution at codon 180 on the prion protein gene.

Biochemical and biophysical research communications - 19 Feb 2018

Ito Yoko, Sanjo Nobuo, Hizume Masaki, Kobayashi Atsushi, Ohgami Tetsuya, Satoh Katsuya, Hamaguchi Tsuyoshi, Yamada Masahito, Kitamoto Tetsuyuki, Mizusawa Hidehiro, Yokota Takanori

Abstract excerpt

Valine-to-isoleucine substitution at codon 180 of the prion protein gene is only observed in patients with Creutzfeldt-Jakob disease and accounts for approximately half of all cases of genetic prion disease in Japan. In the present study, we investigated the biochemical characteristics of valine-to-isoleucine substitution at codon 180 in the prion protein gene, using samples obtained from the autopsied brains of...

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PMID: 29382530
DOI: 10.1016/j.bbrc.2018.01.119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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