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Article

Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia

21 Apr 2020

Abstract excerpt

ABSTRACT Extracellular adenosine mediates diverse anti-inflammatory, angiogenic and vasoactive effects, and has become an important therapeutic target for cancer, which has been translated into clinical trials. This study was designed to comprehensively assess adenosine metabolism in prostate and breast cancer cells. We identified cellular adenosine turnover as a complex cascade, comprising (1) the ectoenzymatic...

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PMID: 32317394
DOI: 10.1242/jcs.241463

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