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Article

Population pharmacogenetic pharmacokinetic modeling for flip-flop phenomenon of enteric-coated mycophenolate sodium in kidney transplant recipients.

European journal of clinical pharmacology - 1 Oct 2014

Han Nayoung, Yun Hwi-yeol, Kim In-Wha, Oh Yoon Jung, Kim Yon Su, Oh Jung Mi

Abstract excerpt

PURPOSE: Enteric-coated mycophenolate sodium (EC-MPS) is effective and safe in preventing rejection after transplantation and is mainly transported by ABCs and OATPs and metabolized by UGTs. The genetic polymorphisms affect the inter-individual variation in drug disposition and elimination. The aims of this study were to develop a population pharmacokinetic (PK) model and to evaluate the influence of genetic and...

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Source

Identifiers

PMID: 25163792
DOI: 10.1007/s00228-014-1728-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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