Article
Lower pre-ART intra-participant HIV-1 pol diversity may not be associated with virologic failure in adults.
PloS one - 1 Jan 2018
Kearney Mary F, Spindler Jonathan, Wiegand Ann, Shao Wei, Haubrich Richard, Riddler Sharon, Lalama Christina M, Hughes Michael D, Coffin John M, Mellors John W
Abstract excerpt
BACKGROUND: Identifying pre-ART factors associated with the emergence of HIV-1 drug resistance is critical for optimizing strategies to prevent virologic failure. A previous study reported that lower pre-ART HIV-1 pol diversity was associated with higher risk of virologic failure in HIV-1-infected children. To investigate this association in adults, we measured HIV-1 diversity with deep sequencing in pre-ART...
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