Article
The cytomegalovirus protein US31 induces inflammation through mono-macrophages in systemic lupus erythematosus by promoting NF-κB2 activation.
Cell death & disease - 24 Jan 2018
Guo Gangqiang, Ye Sisi, Xie Shangdan, Ye Lele, Lin Cong, Yang Min, Shi Xinyu, Wang Fangyan, Li Baoqing, Li Ming, Chen Chaosheng, Zhang Lifang, Zhang Huidi, Xue Xiangyang
Abstract excerpt
It has been hypothesized that human cytomegalovirus (HCMV) infection, especially in monocyte and CD34 (+) myeloid cells, acts as a important regulator of immune system to promote inflammation in multiple autoimmune diseases. The aim of this study was to elucidate the HCMV gene expression profiles in the peripheral blood mononuclear cells (PBMCs) of SLE patients and demonstrate the effect and mechanism of viral...
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